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A prudent path is to assess for folate sensitivity in the history and to quantify methylation statustypically with whole-blood histamine and a methylation pathway panel (SAM, SAH, homocysteine)before attempting high-dose folate

A proper evaluation helps ensure safety and suitability

Substances contacted within Schedule 4 of the Poisons List are considered a s4 medicine as outlined in the Medicines and Poisons Act 2019 (QLD)

Usually found in the brain, it passes quickly through blood barriers

The detection window varies by administration route and testing method

B12 is present in supplements and foods that have been fortified, making them potentially easier to absorb