doi:10.1016/j.mad.2003.11.005 Land SC
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Grewal, A
Apoptosis, the most common form of PCD, is particularly significant, as granulosa cells apoptosis deprives oocytes of the hormones and survival factors essential for their meiotic and developmental competence, which increases the susceptibility of oocytes to apoptotic factors, ultimately impairing ovarian reserve function
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The buildup of free radicals with aging as well as sleep loss, exacerbates the metabolic dysfunctions and risks for age-related morbidity due to cardiovascular and neurodegenerative diseases (Rusu et al., 2020