This mechanism is shared with other well-researched peptides, such as BPC-157, and helps explain GHK-Cus systemic anti-aging potential
Approaches to intervene in lipid metabolic pathways include LOX inhibitors, radical-trapping antioxidants (RTAs, which scavenge lipid hydroxyl radicals), ACSL4 inhibitors, and deuterated PUFAs/MUFAs (by reducing PUFA-containing phospholipids)
Even if iodine is a common treatment for thyroid disorders, too much iodine can trigger thyroid problems
Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: role of nanoparticle-based drug delivery systems in clinical translation
doi: 10.3389/fendo.2025.1633377 Received 22 May 2025 Accepted 17 September 2025 Published 05 November 2025 Volume 16 - 2025 Edited by Senthilkumar Palaniappan, Karpagam Academy of Higher Education, India Reviewed by Sudhanshu Kumar Bharti, Patna University, India Sanaz Alaee, Shiraz University of Medical Sciences, Iran Updates Copyright 2025 Balkrishna, Rana, Mishra, Agrawal, Rajput, Dhanasekaran, Rana, Arya, Ramu, Upadhayay and Singh
Mitochondrial ion accumulation also contributes to the impact of antioxidant therapies [78, 79] that reduce the release/impact of mitochondrial ROS after TBI