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Potential Side Effects and Long-Term Risks Common side effects include nausea, vomiting, digestive issues, and fatigue

Postmarketing Experience Additional adverse reactions have been identified during postapproval use

[59] found greater cortisol reactivity to stress in the luteal phase

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The nasal mucosa is highly vascularized, allowing absorption directly into circulation, and some evidence suggests nasal administration may provide more direct central nervous system access via the olfactory pathway

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