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In this context, RAAS inhibition therapy using small nucleotides or NRP1 activators has demonstrated success, as it directly counteracts the long-term RAAS activation responsible for vascular and cardiac remodeling

The likely protease responsible for the release of famsin is furin, an enzyme of the proprotein convertase subtilisin/kexin (PCSK) type family and as such is also identified as PCSK3

Resolves with continued use or dose reduction