First, the safety profiles under different formulations (such as nanoformulations vs traditional formulations), routes of administration (inhalation vs intravenous), and dose gradients have not been fully clarified, especially the need for systematic evaluation of neurotoxicity and immune regulation effects with long - term use
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Sunny NE, Bril F, Cusi K
5.3.5 Pycnogenol Pycnogenol is a standardized herbal extract with high bioavailability, synergistic effects with other lightening agents, and low toxicity potential through the oral route of administration
[Google Scholar] 5.Jankowski J., Floege J., Fliser D., Bohm M., Marx N
