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glutathione S-transferase gene was not known to exist in lactobacilli till the WGS of Lactobacillus casei Zhang was achieved [14]

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Furthermore, shRNA-mediated silencing of Nrf2 in TC6 mouse insulinoma cells suppressed expression of proteasomal subunit genes Psmb5 and Psmb6 , enhancing toxicity following tunicamycin treatment, which could be prevented by pretreatment with the NRF2 activator 1,2-dithiole-3-thione (107)

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