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Indications for Semaglutide Semaglutide is indicated for chronic weight management in individuals with a body mass index (BMI) of 27 kg/m2 or greater who have at least one weight-related condition or in individuals with a BMI of 30 kg/m2 or greater
Materials and methods Animals and experimental procedure This study was carried out at the Sakarya University Faculty of Medicines Experimental Animal Centre following approval from the Sakarya University Animal Experiments Local Ethics Committee
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The mechanism is multifactorial: weight loss reduces the mechanical load on the cardiovascular system, improved insulin sensitivity reduces sodium retention, and direct vascular effects of GLP-1 receptor activation promote vasodilation