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That dual-agonist approach is likely why tirzepatide consistently outperforms single-pathway GLP-1 therapies in clinical trials, explains Dr
While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments
That awareness alone drives behavior change
While genetics don't determine outcome, certain variants correlate with faster or more modest initial responses
Frontiers in Pharmacology, 2022
However, older adults are also more susceptible to B6-related peripheral neuropathy, and they may already have neuropathy from other causes such as diabetes or vascular disease
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