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Oxidative stress is widely considered to be central to many forms of PD 5

Expert Opinion on Biological Therapy, 18(sup1), 131139

A.Alonso

Tubular epithelial fibroblast transdifferentiation (TEMT) has been proposed as a viable therapeutic option to decrease RF since it stimulates the expression of several fibro-cytokines, which represent a critical mechanism in the development of RF ( SalB mitigates TEMT and has renal protective effects by down-regulating the expression of FGF2/TGF-1/-SMA via the HPSE/Syndecan-l axis ( 2.4.3 PDGF PDGF is a profibrotic mediator that induces fibroblast activation and proliferation and promotes ECM contraction ( SalB in reducing renal inflammation and CTGF production, improving renal function, and inhibiting the progression of RF through the PDGF-C/PDGFR pathway has been well-documented (Yao et al., 2022)

Although a balanced diet is sufficient for many individuals, some people may require additional nutritional support

Moreover, PLC and I B phosphorylation was increased by Con A administration in the spleen of WT mice, whereas those phosphorylation did not increase in the spleen of Gpx1 KO mice with Con A administration (Figure 5c)