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The potential mechanisms underlying this effect include the drugs water solubility, which facilitates its passage through cell membranes, as well as its uptake via OCTs and excretion with the assistance of multidrug and toxin extrusion (MATE) proteins

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elegans GST isoforms have a multitude of functions, and are involved in cell signal pathways via direct protein-protein interactions under H 2 O 2 -stressed and non-stressed conditions [[109], [110], [111], [112]]