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Eric Topol (16:42): Yeah, it's pretty striking

Several mechanisms could theoretically contribute to altered skin sensation or sensitivity during semaglutide therapy, though these remain speculative without robust clinical evidence

By reducing appetite, liraglutide manages blood glucose levels in type 2 diabetes and promotes weight loss

17 While topline results from the headtohead trial of tirzepatide versus semaglutide in people with obesity or overweight without T2D (SURMOUNT5, NCT05822830) recently demonstrated that 72 weeks of tirzepatide treatment led to a greater weight reduction compared with semaglutide (20.2% vs

Novo Nordisk has not yet reported a subgroup analysis for these patients, but such an analysis could offer useful insights into whether GLP-1RAs confer cognitive advantage in this subgroup

BMJ (2015) 350:h56