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FDA contraindications for Zepbound include: Personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) Prior serious hypersensitivity reaction to tirzepatide or any product components Patients requiring careful risk assessment regarding pancreatitis include: History of pancreatitis : The FDA label notes that it is unknown whether patients with a history of pancreatitis are at increased risk while using tirzepatide, as these patients were excluded from clinical trials