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While estimands do not solve all problems of trial design and interpretation, this new concept will enable trials to be designed more appropriately to obtain relevant information to address the clinical question(s) of interest

Pursuing activities such as strength training, resistance training, yoga, or Pilates can preserve and build lean mass, which in turn strengthens bones

PMCID: PMC7942234 ) Cogen AL, Desai K, Elder D, Rosenbach M (2019) Acute photodistributed exanthematous pustulosis associated with liraglutide treatment

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Long-term planning matters