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Besides, linsitinib fails to show activity in patients with metastatic prostate cancer, locally advanced or metastatic adrenocortical carcinoma [158, 161]
Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, Heuvel van den LP, et al: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
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eLife 3 , e03640 (2014)