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21 A randomized study enrolling patients with an HbA 1c of 7.5% to 12% (mean HbA 1c , 9%) was conducted to compare sitagliptin monotherapy with sitagliptin/metformin versus pioglitazone (Actos, Eli Lilly) monotherapy

Additionally, it exhibits protective effects against oxidative stress and has been shown to restore integrity to damaged vasculature and gastrointestinal tissues 2,3

GLP-1 Analogue liraglutide attenuates mutant huntingtin-induced neurotoxicity by restoration of neuronal insulin signaling

Pea-Hernndez

However, there are still questions around P9s mechanism, whether it's present in other bacterial species and whether it influences the secretion of other gut hormones, such as GLP-2 and peptide YY

Vairo GL, et al