Always follow the specific dosage instructions provided by your healthcare professional, regardless of the color
Human users have reported occasional headaches, mild GI discomfort, and transient fatigue
Semaglutide is also not recommended for those with a history of pancreatitis, or serious problems with the pancreas, because it can make these issues worse
Cons of injectable semaglutide Requires selfinjection (which some people dislike)
The NICE ethnic BMI adjustment NICE guideline NG246 (2025) sets a lower obesity threshold of BMI 27.5 for people from South Asian, Chinese, Other Asian, Middle Eastern, Black African, and African-Caribbean backgrounds 3
While gastrointestinal side effects are common with both, tirzepatide may actually be better tolerated for some people