Inflammatory cytokines contribute to brain endothelial cell activation and downregulation of tight junction proteins, such as zonula occludens-1 and claudin-5, resulting in bloodbrain barrier dysfunction [55]
By targeting both of these incretin hormone receptors simultaneously, Mounjaro offers a unique mechanism of action that distinguishes it from other diabetes treatments
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9.2 Future development direction of individualized treatment Significant progress has been made in personalized treatment for T2DM and osteoporosis, yet many challenges remain