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In contrast, too much caffeine can worsen the headache by causing dehydration because caffeine can disturb your sleep cycle and can also trigger headaches

Since this 2012 publication, there has been very little new research into this question

In a 48-week Phase 2 trial published in the New England Journal of Medicine (Sanyal and colleagues, NCT04771273), 293 adults with biopsy-confirmed MASH and fibrosis stage F1 through F3 were randomized 1:1:1:1 to once-weekly subcutaneous survodutide at 2.4, 4.8, or 6.0 mg or placebo, again using a 24-week rapid escalation followed by a 24-week maintenance phase

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Demographic-Specific Signals: What are the Vigilance Insights for Clinicians

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