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Mechanistically, this makes sense

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Exploring the role of oxidative stress in skeletal muscle atrophy: mechanisms and implications cureus 15 3 AlmeidaM.AmbroginiE.HanL.ManolagasS

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Chronic poor nutrition: In dogs that have had inadequate diets over extended periods, the combination of low dietary B12 and a compromised gut from malnutrition can contribute to deficiency