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2.2 Data selection, synthesis and analysis Two reviewers independently extracted data from all eligible studies

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These metabolites traverse the BBB and modulate the hosts nervous system

Evidence that lithium alters phosphoinositide metabolism: chronic administration elevates primarily D- myo -inositol-1-phosphate in cerebral cortex of the rat J Neurochem 1981

Wild-type mice were fed with normal diet, while ApoE / mice were fed with HFD containing 0.15% cholesterol and 41% fat (MD12015, Medicine Ltd, Yangzhou, Jiangsu, China) for eight weeks