Although empagliflozin appeared to have less of a reno-protective effect in patients with HFpEF than with HFrEF, further analyses of EMPEROR-Preserved indicate that this may be related to the endpoint definition used (which excluded renal death and included 40% decrease in eGFR), with positive findings when using the renal endpoint from the DAPA-HF trial (which included renal death and 50% decrease in eGFR) [130, 131]
However, EXOS can be returned to the plasma membrane and re-secreted outside of cells
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Brabletz S, Schuhwerk H, Brabletz T, Stemmler MP
Wegovy has a well-documented safety profile supported by years of clinical use in the UK