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Despite these promising findings, significant gaps in the literature remain

Statistical Analysis A general linear mixed model estimated mean response with 95% confidence intervals (CI)

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Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took 600 mg of lipoic acid three times a day for three weeks compared to those who took a placebo (75)