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however, the clinical effect was marginal and patient preference did not differ from placebo

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[1] [2] Strategic timing of tirzepatide administration may help some patients manage common adverse effects, particularly gastrointestinal symptoms that occur during initial treatment and dose escalation

These are decisions that have to be made between a patient and their provider, not by a website

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Starting with a lower dose can help minimize side effects and make the experience more comfortable, especially for first-time clients