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they promote vasodilation by enhancing NOS activity, promoting NO production, increasing cyclic guanosine monophosphate (cGMP) levels, maintaining NO-cGMP pathway activity, down-regulating arginase II protein expression, and reducing competitive consumption of L-arginine

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This knowledge might be critically important for identifying patients who benefit most from the therapy with purified AAT protein and/or specific drugs with antioxidant potentials

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In contrast, male-specific isoforms of P450 have been identified in the rat (Hanioka et al