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Specific considerations for Retatrutide research include: Cardiac Monitoring: Due to Glucagons effect on the heart, monitoring heart rate and rhythm is vital in animal or cellular models

Others (eg Bradley JN, et al.Diab 2017 and Yang A, et al EClin Med 2024) have also reported worsening glycemic control following metformin discontinuation

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In addition, large amounts of the mitochondria-specific phospholipid cardiolipin (CL) were administered by oxidative modification in GPX4 -/- kidneys[33]

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