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Retatrutides ~144-hour half-life and tirzepatides ~120-hour half-life both support a single weekly subcutaneous dose, the schedule used in every registrational trial

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Prior to initiating saxagliptin, vildagliptin or alogliptin: Check liver and kidney function During treatment: Vildagliptin: Monitor liver function tests (LFTs) at 3-monthly intervals post-initiation for the first year and periodically thereafter

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The treatment of choice is oral acyclovir.5 Chronic paronychia Persistent inflammation of the nail folds, which may cause secondary onychodystrophy if the matrix is involved