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Most preclinical studies are conducted in young, healthy, genetically homogeneous male rodents, far removed from the heterogeneity of aging human populations with comorbidities such as hypertension, diabetes, or cerebrovascular disease

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Key Takeaways GLP-1 receptor agonists have been linked to both positive and negative mental health outcomes

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The dual nature of free radicals plays a crucial role in human physiology and pathology

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