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Thus, CDO1 is a metabolic liability for NSCLC cells with high intracellular cysteine, particularly NRF2/KEAP1 mutant cells (Kang et al., Elife 2019)

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The glucagon receptor activation could theoretically either worsen or improve energy levels, as glucagon promotes glycogen breakdown and fat oxidation, potentially providing more available fuel

The defocus range was set from 1.5 to 3 m