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413 Partial ablation of astrocytes in the prefrontal cortex of healthy rats (by injection of gliotoxin L--aminoadipic acid) resulted in the development of depressive-like behaviours, whereas injection of neurotoxin ibotenate did not have such an effect

This also indicates a role of APLN/APLNR signaling in the regulation of immunological processes, which needs to be further investigated

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Clinical and preclinical research demonstrates that maintaining optimal GSH levels supports liver function, immune cell activity, mitochondrial protection, and overall cellular homeostasis [3] [9]

(Dordr) 44, 357372

doi: 10.3390/ijms24032767 6 DasariS.GonuguntlaS.GanjayiM