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NRF2 enhances the expression of genes involved in glutathione biosynthesis and the detoxification of lipid peroxidation products [10]

5a, diamide exposure markedly increased intracellular protein-GSSG adduct formation

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VEGFR-2 activation initiates several signaling pathways leading to specific endothelial responses such as cell survival, proliferation, migration, invasion, vascular permeability and vascular inflammation [121]

Skin barrier and tolerance: Impaired skin barrier function allows increased exposure to environmental antigens and microbes

McKenna MJ, Medved I, et al