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The FDA label for rosuvastatin recommends a maximum of 20 mg daily when combined with "certain OATP1B1 inhibitors" but lists specific agents (lopinavir/ritonavir, atazanavir/ritonavir, simeprevir) [4]
CI 95% 0.4260.987) and in those without (HR 0.52
[DOI] [PMC free article] [PubMed] [Google Scholar] 93
The broader receptor profile of these newer-generation GLP-1 receptor agonists is thought to offer clinical advantages, potentially providing better tolerability or enhanced effectiveness due to simultaneous modulation of reward-related neural circuits and metabolic pathways (Ray 2023
Dose adjustments of these medications may be necessary, particularly in patients with diabetes
Ibid., p
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