Nutr Metab Cardiovasc Dis NMCD
DPP-4 inhibitors (gliptins) Shortly after the demonstration that the enzyme DPP-4 is responsible for the rapid inactivation of GLP-1, the idea of inhibiting DPP-4 to prolong the duration of action of GLP-1 (and glucose-dependent insulinotropic polypeptide [GIP]) was put forward (reviewed in [34])
Pedre, B
Contact your GP or prescribing clinician if you experience : Severe or rapidly progressive hair loss , particularly if it occurs in patches rather than diffuse thinning Hair loss accompanied by scalp symptoms such as redness, scaling, itching, pain, or visible inflammation (which may indicate scarring alopecia requiring urgent dermatology referral) Signs of potential nutritional deficiency , including persistent fatigue, weakness, pallor, brittle nails, mouth ulcers, or neurological symptoms Hair loss persisting beyond 69 months or worsening despite nutritional optimisation Significant psychological distress related to hair changes affecting your quality of life Your healthcare provider may recommend blood tests to investigate potential underlying causes, which might include: Full blood count : To assess for anaemia Ferritin levels : To evaluate iron stores (aim to treat iron deficiency to within the laboratory reference range) Thyroid function tests : To exclude hypothyroidism or hyperthyroidism Vitamin B12 and folate : Particularly relevant if dietary intake is restricted Coeliac serology : May be considered if iron deficiency is present without obvious cause Zinc levels : Though testing can be unreliable, may be considered in specific circumstances Depending on findings, your GP may suggest adjusting your GLP-1 dosage , slowing the rate of weight loss, or referring you to a dermatologist for specialist assessment if hair loss appears atypical or fails to improve
BlehaRShevtsovaTVivkovMKorbovAJekovMSaloIet al
Patients should be aware of red-flag symptoms requiring urgent medical attention, including severe, persistent abdominal pain (with or without vomiting) which may suggest pancreatitis, signs of allergic reaction, or symptoms of gallbladder disease
