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Animals The GCLM knockout (KO) mouse line (characterized previously 16 ) has been backcrossed into the C57BL/6J background for more than 10 generations
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Kojic Acid: Derived from fungi, kojic acid is renowned for its ability to inhibit melanin production
For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34
