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The DAC modification significantly prolongs the half-life of the peptide, providing more consistent stimulation of GH release. Teichman et al., Journal of Clinical Endocrinology & Metabolism Modified GRF (1-29) aka CJC-1295 without DAC: This shorter-acting version has a half-life of 30 minutes to 2 hours , mimicking natural GH pulses more closely

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Mellingen RM, Myrmel LS, Rasinger JD, Lie KK, Bernhard A, Madsen L, Nstbakken OJ (2022) Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice