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Reversal of hepatic proliferative focal lesion growth and even hepatocellular neoplasms has been reported following cessation of treatment with phenobarbital, dieldrin, and chlordane in these models (Kolaja et al

HIF-1 overexpressed under hypoxic conditions contributes to aggressive phenotypes in tumor cells [13]

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At the dose administered, the nanoparticle polymer was well tolerated via the nasal route