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In contrast, semaglutide works through a different mechanism that does not affect urinary glucose excretion

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When prescribed medically for example, in adults with confirmed growth hormone deficiency synthetic HGH works by binding to growth hormone receptors throughout the body, stimulating the production of insulin-like growth factor 1 (IGF-1) in the liver

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All studies had estimands which aligned with the definitions of treatment regimen and efficacy estimands, except for SCALE Obesity and Prediabetes which did not report on the efficacy estimand