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The participants self-monitored their vital signs daily, had weekly telehealth visits with a nurse, and were provided educational videos to view throughout the program (with all components delivered in the participants language of choice, English or Spanish)

That does not make it an approved treatment, but it does make it easier to study as a defined research compound

The typical protocol of 2-5 mg twice weekly translates to 16-40 mg monthly usage

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10.1016/j.cgh.2013.07.001 14

The existence of such a trial reflects growing confidence in prolotherapys potential, as well as a need to quantify its efficacy under controlled conditions