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In addition, GLP-1RA, including liraglutide (10), dulaglutide (8), and exenatide (11), has shown renal benefits in clinical trials

Variants in genes encoding GLP-1 receptors, GIPR signaling pathways, and metabolic regulators like FTO and MC4R influence both initial weight loss velocity and the likelihood of hitting a plateau

doi:10.1007/s00125-024-06321-2 43

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That process requires cell membranes that stay structurally intact, mitochondria that produce energy efficiently, and antioxidant systems that clear damage before it compounds

Husain M, Birkenfeld AL, Donsmark M, for the PIONEER 6 Investigators, et al