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SURMOUNT-1 and STEP-1: Obesity-Specific Trials SURMOUNT-1 (Tirzepatide for Obesity, NEJM 2022): At the maximum 15 mg dose, participants without diabetes lost an average of 22.5% of their body weight over 72 weeks approximately 51 lbs for a 225-lb person
Oral and capsule versions are less studied and may require higher doses for comparable results
Although orange juice is also a good source of folate, consumption should be limited to 4 oz per day to prevent rapid increases in blood sugar levels
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