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Oxidized LDL triggers an inflammatory cascade monocytes migrate into the intima and differentiate into macrophages, engulfing lipids to form foam cells

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Zileuton, an FDA-approved oral medication for treating asthma, is an ALOX5 inhibitor that exerts neuroprotective effects by blocking ALOX5-mediated glutamate toxicity and ferroptosis in HT22 cells, a mouse hippocampal cell line [301]

Patients considering these medications should understand they are being used off-label for this indication, and expectations should be carefully managed regarding potential benefits and limitations

The views expressed are those of the authors and not necessarily those of the funders

Daily exercise works well to regulate your circulation and thermoregulatory system