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Maximum daily dosage: Not applicable, as this is a once-weekly medication

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As of mid-2025, retatrutide remains in Phase 3 clinical trials (see ClinicalTrials

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It neutralizes the stomach acid long enough for the GLP-1 to be absorbed into the bloodstream, retaining higher bioavailability, though still not as high as injectable GLP-1s

This suggests the peptide might help regulate the neuroendocrine response when things get challenging