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In response, Empower told the FDA that it was improving its manufacturing processes, but in 2018, the FDA investigators again noted in an inspection report that Empower was not adequately investigating problems with sterile drug quality

In a recent, large, matched case-control study, cardiovascular symptoms and signs, including palpitations, chest pain, dyspnea, cough, orthopnea, displaced apex, cardiac murmur, chest wheeze/crepitus were much more frequent in hyperthyroid patients than in controls, and some of them persisted despite effective restoration of euthyroidism by antithyroid drug treatment (182)

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