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When they administered semaglutide to lab animals, the c-Fos distribution indicated that a number of brain regions were being indirectly activated by the GLP-1R agonist that had not shown up as being directly activated (Gabery et al., 2020)
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Officially, the FDA cites: Insufficient large-scale clinical trials Concerns about consistency, sourcing, and manufacturing standards The need to meet formal drug approval requirements Critics argue (fairly) that this system: Favors large pharmaceutical companies Makes it hard to approve naturally occurring peptides Leaves promising, low-risk compounds in regulatory limbo The short version: This FDA restrictive regulatory change of mind wasnt driven by a sudden safety scare, it was driven by regulatory process and economics
G., Maas, R
Adequate protein: Helps maintain muscle mass during weight loss and supports satiety
