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For the present review, a literature search was performed in the PubMed ( and PubMed Central (PMC) ( databases using topics and subtopics associated with the role of one-carbon metabolism (such as MTHFR, folate and homocysteine), epigenetic mechanisms (such as DNA methylation and histone modification) and their impact on autoimmune diseases such as RA, SLE, MS, cEd and FM

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