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The freed B12 then binds to intrinsic factor, a protein produced by gastric parietal cells, forming a complex that travels to the terminal ileum (the last section of the small intestine) where it is absorbed into the bloodstream

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[9] The European Food Safety Authority (EFSA) also confirms that absorption through oral route drops significantly when doses exceed 1-2 mcg, meaning high-dose tablets rely mostly on passive absorption, which is inconsistent

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SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)