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Recent systemic review and meta-analysis demonstrated, that treatment with functional agonists of GLP-1 which included both GLP-1RAs and DPP4 inhibitors resulted in a significant reduction of depression rating scores and tended to be superior over control treatments, which supports the hypothesis of their antidepressant action in humans

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Many of the courts, however, allow for an exception when it comes to "establishment claims"claims that the product is "clinically proven" or "clinically shown" to offer the stated benefitfinding that the claim could itself be misleading and actionable if the product is not backed by the claimed clinical test or study