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This means the body depends on a steady dietary supply to maintain adequate levels for vital physiological functions [31]

Costs associated with unspecified vitamin B12 deficiency-related macrocytic anemia can be reimbursed

Removing pyruvate in the media prevents the recycling of NADH into NAD + by the cytosolic LDH enzyme, forcing mitochondrial redox shuttle systems to support cytosolic redox balance 18

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