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[2] Your mental health has gotten worse In some cases, semaglutide can cause changes in mood, including symptoms of anxiety and depression

**Never shake.** Shaking denatures peptide bonds and can reduce potency

GLP-1 and GIP receptor activation produces gastrointestinal effects (nausea, reduced appetite) that are dose-dependent

PMID:33567185 Davies, M., et al

PlexusDx does not sell, prescribe, or recommend retatrutide or any other investigational peptide in this category

Stability at a glance: Lyophilized powder at minus 20C: stable for many months Bacteriostatic water solution at 2 to 8C: roughly 28 days Sterile water solution at 2 to 8C: a few days at most Single-use aliquots frozen at minus 20C: the longest option, but freeze only once Proper Documentation and Labeling Methods Good records turn a vial into reliable data