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In a rat model of pulmonary arterial hypertension (PAH) induced by a single dose of monocrotaline, OXR1 and P21 gene expression and antioxidant capacity in lung tissue significantly decreased

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It is postulated that DM-induced oxidative damage may be more significant in erythrocytes than in other cells, due to their high content of iron and polyunsaturated fatty acids, as well as their role as oxygen transporters, with a high degree of exposure to free radicals [320]

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